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Herbal melanin inhibits colorectal cancer cell proliferation by altering redox balance, inducing apoptosis, and modulating MAPK signaling Authors Omar Al‑Obeed1†, Adila Salih El‑Obeid2,3†, Sabine Matou‑Nasri4†, Mansoor‑Ali Vaali‑Mohammed1, Yazeid AlHaidan4, Mohammed Elwatidy1, Hamad Al Dosary1, Zeyad Alehaideb4, Khayal Alkhayal1, Adil Haseeb5, James McKerrow6, Rehan Ahmad1 and Maha‑Hamadien Abdulla1* Abstract Background Colorectal carcinoma is one of the most […]

Herbal Melanin Inhibits Real-Time Cell Proliferation, Downregulates Anti-Apoptotic Proteins and Upregulates Pro-Apoptotic p53 Expression in MDA-MB-231 and HCT-116 Cancer Cell Lines Abstract Background and Objectives: Cancer is the second-most-important deadly disease in the world, leading to severe socioeconomic consequences and posing a public threat. Consequently, breast and colorectal cancers are significant cancer types that affect women and

Herbal Melanin Induces Interleukin-1β Secretion and Production by Human THP-1 Monocytes via Toll-Like Receptor 2 and p38 MAPK Activation Abstract Herbal melanin (HM), extracted from Nigella sativa, is known for its immunogenic properties through the modulation of cytokine production via Toll-like receptor (TLR)4. TLRs play a crucial role in the host defense through the regulation